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ea0042p9 | (1) | Androgens2016

The deubiquitinating enzyme USP12 controls prostate cancer cell survival by regulating the AR-AKT-p53 signalling network

McClurg Urszula L , Chit Nay C T H , Nakjang Sirintra , Edwards Joanne , McCracken Stuart R , Robson Craig N

We previously demonstrated that USP12 functions as an AR co-activator by directly deubiquitinating the AR and stabilising its protein levels. Additionally, we showed that USP12 targets the PHLPP AKT phosphatases leading to decreased levels of activated, phosphorylated AKT (pAKT) and as such indirectly stabilises the AR preventing its phosphorylation at serine 213. We further investigated the role of USP12 in prostate cancer by analysing the transcriptome of the LNCaP prostate ...

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ea0042oc10 | (1) | Androgens2016

Glycosylation is a global target for androgen control in prostate cancer cells

Munkley Jennifer , Livermore Karen E. , Vodak Daniel , James Katherine , Wilson Brian T. , McClurg Urszula L. , Knight Bridget , MCcullagh Paul , Mcgrath John , Crundwell Malcolm , Harries Lorna W. , Leung Hing Y. , Robson Craig N. , Oltean Sebastian , Mills Ian G. , Rajan Prabhakar , Elliott David J.

Changes in glycan composition are common in cancer and can play important roles in all of the recognised hallmarks of cancer (1). We recently identified glycosylation as a global target for androgen control in prostate cancer cells and further defined a set of 8 glycosylation enzymes (GALNT7, ST6GalNAc1, GCNT1, UAP1, PGM3, CSGALNACT1, ST6GAL1 and EDEM3), which are also significantly up-regulated in prostate cancer tissue (4). These 8 enzymes are under direct control of the and...

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Endocrine Abstracts

The deubiquitinating enzyme USP12 controls prostate cancer cell survival by regulating the AR-AKT-p53 signalling network

Glycosylation is a global target for androgen control in prostate cancer cells

BiosciAbstracts